Evaluation of antimycobacterial, leishmanicidal and antibacterial activity of three medicinal orchids of Arunachal Pradesh, India

The ethnic population of Arunachal Pradesh uses a number of orchids as such, or in decoction for various ailments. Three untapped orchids namely, Rhynchostylis retusa, Tropidia curculioides and Satyrium nepalense...

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Centella asiatica modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC’s)

Cancer cachexia is associated with increased pro-inflammatory cytokine levels. Centella asiatica (C. asiatica) possesses antioxidant, anti-inflammatory and anti-tumour potential. We investigated the modulation of...

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Anti-tumor and anti-angiogenic effects of Fucoidan on prostate cancer: possible JAK-STAT3 pathway

Prostate cancer is the most common cancer in men in the United States. Fucoidan is a bioactive polysaccharide extracted mainly from algae. The aim of this study was to investigate anti-tumor and anti-angiogeni...

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Effects of the combined extracts of Herba Epimedii and Fructus Ligustrilucidi on airway remodeling in the asthmatic rats with the treatment of budesonide

Asthma is characterized by chronic airway inflammation, leading to structura1 changes in the airway, collectively termed airway remodeling. Airway remodeling is thought to contribute to airway hyper responsive...

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Towards personalized dosimetry with 32P microparticle therapy for advanced pancreatic cancer

A Monte Carlo particle simulation platform was developed to model the dosimetry of 32P microparticle internal radionuclide treatment for advanced pancreatic cancer. Patient-specific dosimetry simulations based on data from previous 32P microparticle clinical studies demonstrated the importance of considering non-uniform dose distributions as well as relative dynamic changes in tumor volume and dose rate during treatment. These results will be valuable in designing future personalized treatment strategies.

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A phase I/II dose escalation study of the use of intensity modulated radiotherapy (IMRT) to treat the prostate and pelvic nodes in patients with prostate cancer

Elective pelvic lymph node (PLN) radiotherapy and hypofractionation for advanced localised prostate cancer remains controversial. We report a single-centre sequential cohort study using IMRT to deliver conventionally-fractionated 50Gy, 55Gy, and 60Gy to the PLN and 70-74Gy (2Gy/fraction) to the prostate. Additionally we studied modest hypofractionation delivering 60Gy (3Gy/fraction) to the prostate with 47Gy to the PLN over 4-5 weeks. Our findings highlight the safety of dose-escalation and hypofractionation in PLN-IMRT.

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Non-iterative geometric approach for inverse kinematics of redundant lead-module in a radiosurgical snake-like robot

Snake-like robot is an emerging form of serial-link manipulator with the morphologic design of biological snakes. The redundant robot can be used to assist medical experts in accessing internal organs with min...

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