Molecular Systems Biology

Antibody Fab‐Fc properties outperform titer in predictive models of SIV vaccine‐induced protection

Fab‐Fc array measurements are used to analyse humoral responses to vaccination. Accounting for antibody qualities and not just the overall response magnitude allows predictive modeling of protection in two different simian immunodeficiency virus (SIV) vaccine studies. Srivamshi Pittala, Kenneth Bagley, Jennifer A Schwartz, Eric P Brown, Joshua A Weiner, Ilia J Prado, Wenlei Zhang, Rong Xu, Ayuko Ota‐Setlik, Ranajit Pal, Xiaoying Shen, Charles Beck, Guido Ferrari, George K Lewis, Celia C LaBranche, David C Montefiori, Georgia D Tomaras, Galit Alter, Mario Roederer, Timothy R Fouts, Margaret E Ackerman and Chris Bailey‐Kellogg Published online 02.05.2019

Absolute quantification of translational regulation and burden using combined sequencing approaches

A sequencing‐based method is developed to quantify transcriptional and translational processes, enabling high‐throughput measurements in absolute units of genetic regulatory components and the burden synthetic genetic constructs place on the host cell. Thomas E Gorochowski, Irina Chelysheva, Mette Eriksen, Priyanka Nair, Steen Pedersen and Zoya Ignatova Published online 03.05.2019

Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks

Transcriptome profiling and genome‐scale mapping of DNAmethylation, seven histone modifications, nucleosome positions, chromatin accessibility, EBF1 and CTCF binding are performed in B cells from CLL patients and healthy donors. Jan‐Philipp Mallm, Murat Iskar, Naveed Ishaque, Lara C Klett, Sabrina J Kugler, Jose M Muino, Vladimir B Teif, Alexandra M Poos, Sebastian Großmann, Fabian Erdel, Daniele Tavernari, Sandra D Koser, Sabrina Schumacher, Benedikt Brors, Rainer König, Daniel Remondini, Martin Vingron, Stephan Stilgenbauer, Peter Lichter, Marc Zapatka, Daniel Mertens and Karsten Rippe Published online 22.05.2019

Corrigendum

INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases

Robin Beekhof, Carolien van Alphen, Alex A Henneman, Jaco C Knol, Thang V Pham, Frank Rolfs, Mariette Labots, Evan Henneberry, Tessa YS Le Large, Richard R de Haas, Sander R Piersma, Valentina Vurchio, Andrea Bertotti, Livio Trusolino, Henk MW Verheul and Connie R Jimenez Published online 24.05.2019

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