In vitro and intracellular activity of imipenem combined with tedizolid, rifabutin, and avibactam against Mycobacterium abscessus [Mechanisms of Action]

Mycobacterium abscessus infections are difficult to treat due to resistance to many antibiotics. In vitro, tedizolid combined with imipenem displayed a moderate synergistic effect (FIC index of 0.41) but no bactericidal activity. Intracellularly, tedizolid at 2 μg/mL (1/2 of the MIC), corresponding to the peak serum concentration, increased the efficacy of imipenem at 8 and 32 μg/mL. Addition of avibactam and rifabutin, alone or in combination, improved the activity of the imipenem-tedizolid combination.

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