Higher Reported Lung Dose Received during Total Body Irradiation for Allogeneic Hematopoietic Stem Cell Transplantation in Children with Acute Lymphoblastic Leukemia is Associated with Inferior Survival: A Report from the Children’s Oncology Group

A secondary analysis of data from a phase III trial demonstrated no difference in relapse and inferior survival of patients receiving the lung dose ≥800cGy as part of their TBI regimen. TBI techniques, including the methods of lung dose calculation, were heterogeneous across the institutions participating in this study. These findings led to recommendations of lung-shielding above 800cGy for COG TBI protocols and triggered phantom-based dosimetry investigation of TBI techniques across the institutions.

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