Accumulation of prion protein in the vagus nerve in Creutzfeldt‐Jakob disease

Abstract

Disease‐associated proteins are thought to propagate along neuronal processes in neurodegenerative diseases. To detect disease‐associated prion protein (PrP^Sc) in the vagus nerve in different forms and molecular subtypes of Creutzfeldt‐Jakob disease (CJD) we applied three different anti‐PrP antibodies. We screened the vagus nerve in 162 sporadic and 30 genetic CJD cases. 4/31 VV‐2 type sporadic CJD and 7/30 genetic CJD cases showed vagal PrP^Sc immunodeposits with distinct morphology. Thus PrP^Sc in CJD affects the vagus nerve analogously to α‐synuclein in Parkinson's disease. The morphologically diverse deposition of PrP^Sc in genetic and sporadic CJD argues against uniform mechanisms of propagation of PrP^Sc.

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