A novel microscopic assay reveals heterogeneous regulation of local endothelial barrier function

Blood vessels are covered with endothelial cells on their inner surfaces forming a selective and semipermeable barrier between the blood and the underlying tissue. Many pathological processes such as inflammation or cancer metastasis are accompanied by an increased vascular permeability. Progress in live cell imaging techniques has recently revealed that the structure of endothelial cell contacts is constantly reorganized and that endothelial junctions display high heterogeneities at a subcellular level even within one cell.

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