Upregulated osterix promotes invasion and bone metastasis and predicts for a poor prognosis in breast cancer

Upregulated osterix promotes invasion and bone metastasis and predicts for a poor prognosis in breast cancer

Upregulated osterix promotes invasion and bone metastasis and predicts for a poor prognosis in breast cancer, Published online: 10 January 2019; doi:10.1038/s41419-018-1269-3

Osx facilitates bone metastasis of breast cancer by upregulating the expression of a cohort of genes that contribute to steps in the metastatic cascade. These genes include MMP9, VEGF, as well as IL-8, PTHrP, and MMP13. MMP9 is a newly identified target of Osx. .

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