TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment

Oro and colleagues describe epigenomic landscapes of epidermal lineage commitment from human PSCs. By delineating transcriptional and chromatin-regulatory networks, they identify TFAP2C and p63 as key factors for surface ectoderm initiation and keratinocyte maturation, respectively, and reveal TFAP2C-p63 feedback regulation of epigenetic transitions during lineage commitment.

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