Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors

Feige and colleagues report that aging impairs matricellular signals in the skeletal muscle stem cell niche by affecting the function of fibro-adipogenic progenitors (FAPs). Aged FAPs secrete less matricellular WISP1, leading to impaired myogenic commitment of muscle stem cells (MuSCs). Restoration of WISP1 levels in the aged niche rejuvenates MuSCs and improves muscle regeneration.

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