Effect of Antihypertensive Medications on Sepsis-Related Outcomes: A Population-Based Cohort Study

Objectives: Although the effect of antihypertensive agents on sepsis has been studied, evidence for survival benefit was limited in the literature. We investigated differences in sepsis-related outcomes depending on the antihypertensive drugs given prior to sepsis in patients with hypertension. Design: Population-based cohort study. Setting: Sample cohort Database of the National Health Insurance Service from 2003 to 2013 in South Korea. Patients: Patients over 30 years old who were diagnosed with sepsis after receiving hypertension treatment. Interventions: None. Measurements and Main Results: Primary outcomes, 30-day and 90-day mortality rates, were analyzed for differences among three representative antihypertensive medications: angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers, calcium channel blockers, and thiazides. In total, 4,549 patients diagnosed with hypertension prior to hospitalization for sepsis were identified. The 30-day mortality was significantly higher among patients who did not receive any medications within 1 month before sepsis (36.8%) than among patients who did (32.0%; p

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