Nanocarriers and Their Loading Strategies

The drug loading process of nanocarriers is a key step in synthesis of nano‐medicine. Through systematic review of loading strategies and making comparison across diverse systems in the field, it is hoped that new understanding and new concepts can be brought to inspire the synthesis flexibility of nanocarriers, and the newstrategies to improve the effectiveness of chemotherapy agent are put forward.

Abstract

Nanocarriers are of paramount significance for drug delivery and nanomedicine technology. Given the imperfect systems and nonideal therapeutic effects, there are works to be done in synthesis as much as in biological studies, if not more so. Building the foundation of synthesis would offer more tools and deeper insights for exploring the biological systems with extreme complexity. This review aims at a broad‐scope summary and classification of nanocarriers for drug delivery, with focus on the synthetic strategy and structural implications. The nanocarriers are divided into four categories according to the loading principle: molecular‐level loading, surface loading, matrix loading, and cavity loading systems. Making comparisons across diverse nanocarrier systems would make it easier to see the fundamental characteristics, from where the weakness can be addressed and the strengths combined. The systematic comparisons may also inspire new ideas and methods.

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