Downregulation of lncRNA OIP5‐AS1 inhibits breast cancer progression by targeting SOX2 via miRNA‐129‐5p upregulation

Abstract

Several studies have demonstrated an important role for long non‐coding RNA (lncRNA) in breast cancer progression. This study investigated the role of the lncRNA OIP5‐AS1 in the progression of breast cancer. OIP5‐AS1 was significantly upregulated in breast cancer tissues and breast cancer cell lines, and OIP5‐AS1 downregulation inhibited the malignant behaviors of breast cancer in vitro and in vivo. For the depth exploration of mechanism of OIP5‐AS1 in breast cancer, we found that miR‐129‐5p which was found had bind sites in the sequence of OIP5‐AS1, expression in breast cancer tissues was negatively correlated with OIP5‐AS1 and luciferase assays indicated that OIP5‐AS1 acted as miR‐129‐5p sponge, resulting in upregulated expression of the SOX2 transcription factor. Our study revealed that OIP5‐AS1 plays a critical role in promoting breast cancer progression and that OIP5‐AS1 downregulation targets SOX2 via miR‐129‐5p upregulation.

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