Deep learning-based preoperative predictive analytics for patient-reported outcomes following lumbar diskectomy: Feasibility of center-specific modelling

Publication date: Available online 16 November 2018

Source: The Spine Journal

Author(s): Victor E. Staartjes, Marlies P. de Wispelaere, W. Peter Vandertop, Marc L. Schröder

Abstract

Background Context

There is considerable variability in patient-reported outcome measures (PROM) following surgery for lumbar disk herniation (LDH). Individualized prediction tools that are derived from center- or even surgeon-specific data could provide valuable insights for shared decision-making.

Purpose

To evaluate the feasibility of deriving robust deep learning-based predictive analytics from single-center, single-surgeon data.

Study Design

Derivation of predictive models from a prospective registry.

Patient Sample

Patients who underwent single-level tubular microdiskectomy for LDH.

Outcome Measures

Numeric rating scales (NRS) for leg and back pain severity and Oswestry Disability Index (ODI) scores at 12 months postoperatively.

Methods

Data were derived from a prospective registry. We trained deep neural network-based and logistic regression-based prediction models for PROM. The primary endpoint was achievement of the minimum clinically important difference (MCID) in NRS and ODI, defined as a 30% or greater improvement from baseline. Univariate predictors of MCID were also identified using conventional statistics.

Results

A total of 422 patients were included (mean [SD] age: 48.5 [11.5] years; 207 [49%] female). After 1 year, 337 (80%), 219 (52%), and 337 (80%) patients reported a clinically relevant improvement in leg pain, back pain, and functional disability, respectively. The deep learning models predicted MCID with high area-under-the-curve (AUC) of 0.87, 0.90, and 0.84, as well as accuracy of 85%, 87%, and 75%. The regression models provided inferior performance measures for each of the outcomes.

Conclusions

Our study demonstrates that generating personalized and robust deep learning-based analytics for outcome prediction is feasible even with limited amounts of center-specific data. With prospective validation, the ability to preoperatively and reliably inform patients about the likelihood of symptom improvement could prove useful in patient counselling and shared decision-making.

https://ift.tt/2Q3vHut