Administration of dendritic cells and anti-PD-1 antibody converts X-ray irradiated tumors into effective in situ vaccines

Although localized X-ray therapy can induce a systemic anti-tumor immune response, radiation alone may not be sufficient to control both primary and metastatic tumors. Using B16/BL6 and LLC mouse models, controls of primary and metastatic tumors were evaluated after X-ray irradiation followed by administrations of bone marrow derived dendritic cells and anti-PD1 antibody. This triple combination induced a remarkable CD8 mediated anti-tumor immune response inhibiting both local and metastatic tumor growth and extending survival significantly.

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