Stage-Specific Transcription Factors Drive Astrogliogenesis by Remodeling Gene Regulatory Landscapes

Neural stem cells give rise to both neurons and glia. Modeling gliogenesis in vitro, Tiwari et al. show that the generation of astrocytes involves several transcriptionally and epigenetically distinct stages. The authors found that the transcription factors NFIA, ATF3, and RUNX2 play pivotal roles in establishing these stages.

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