Can the Probiotic Lactobacillus reuteri Be Used to Treat Infant Colic?

The search identified 282 abstracts, of which 4 double-blind randomized controlled trials (345 patients, 171 placebo and 174 probiotic) met the inclusion criteria.2-5 All studies used the same probiotic, manufactured by the same company and given at the same dose, and the same placebo. All trials included breastfed infants with colic, whereas only one trial included formula-fed infants with colic. The probiotic group was approximately twice as likely as the placebo group to experience treatment success at 7, 14, and 21 days (adjusted incidence ratios were 2.08 [95% CI 1.26 to 3.42], 1.98 [95% CI 1.46 to 2.70], and 1.71 [95% CI 1.35 to 2.15], respectively) (Table).

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