Reassessing colectomy in young patients with familial adenomatous polyposis

Familial adenomatous polyposis (FAP) is an autosomal dominantly inherited syndrome caused by a germline mutation in the APC gene that accounts for approximately 1% of colorectal cancer cases in the United States. Mutations between codons 169-1393 result in classic FAP, whereas mutations closer to the 5' and 3' of the APC gene cause attenuated FAP, which has a less severe phenotype.1 FAP is characterized by the development of multiple adenomatous colorectal polyps in childhood and adolescence, which inevitably progresses to colorectal carcinoma.

https://ift.tt/2NCLnn7