Preoperative Intensity-Modulated Radiotherapy Compared To Three-Dimensional Conformal Radiotherapy For High-Grade Extremity Sarcomas In Children: Analysis of the Childrens Oncology Group Study Arst0332

We assessed differences in target coverage and dose to functional structures at risk in pediatric patients with extremity non-rhabomyosarcoma soft tissue sarcomas treated with preoperative radiotherapy using IMRT versus 3D-CRT. Preoperative IMRT was associated with improved target coverage and reduced volume of skin and nearby joint treated to higher doses, warranting further investigation to understand if acute wound complications and late musculoskeletal injury might be influenced by treatment technique.

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