Association Between Plasma Level of Collagen Type III alpha 1 Chain and Development of Strictures in Pediatric Patients With Crohn’s Disease

There are few serum biomarkers to identify patients with Crohn's disease (CD) who are at risk for stricture development. The extracellular matrix components, collagen type III alpha 1 chain (COL3A1) and cartilage oligomeric matrix protein (COMP), could contribute to intestinal fibrosis. We investigated whether children with inflammatory CD (B1) who later develop strictures (B2) have increased plasma levels of COL3A1 or COMP at diagnosis, compared to children who remain B1. We compared results to previously studied biomarkers, including autoantibodies against colony stimulating factor 2 (CSF2).

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