Physiological Calcium Concentrations Slow Dynamics at the Lipid-Water Interface

Phospholipids can interact strongly with ions at physiological concentrations, and these interactions can alter membrane properties. Here we describe the effects of calcium ions on the dynamics in phospholipid membranes. We used a combination of time-resolved ultrafast two-dimensional infrared (2D IR) spectroscopy and molecular dynamics (MD) simulations. We found that millimolar Ca2+ concentrations lead to slower fluctuations in the local environment at the lipid-water interface of membranes with phosphatidylserine.

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