Cerebellar impairment during an orthostatic challenge in patients with neurogenic orthostatic hypotension

Neurogenic Orthostatic Hypotension (NOH) is a cardinal feature of autonomic dysfunction. NOH is clinically defined as a sustained reduction in systolic blood pressure (SBP) ≥30mmHg or diastolic blood pressure of ≥15mmHg within 3 minutes of standing or head-up tilt performed at 60°(Freeman et al. 2011). NOH is unique in that the orthostatic component relates to an excessive BP drop associated with an upright/standing position and the neurogenic component highlights a failure of the autonomic nervous system to reflexively increase sympathetic outflow to counteract the BP drop.

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