Is the Liberal Use of Oxygen Associated With Worse Outcomes Among Critically Ill Patients?

The search strategy identified 1,784 total records, of which 25 studies (16,037 patients) met the inclusion criteria. Studies included 3 trials of oxygen in critical illness, 1 trauma study, 2 sepsis studies, 7 stroke studies, 6 myocardial infarction studies, 2 cardiac arrest studies, and 4 emergency surgery studies. Twelve of 25 trials excluded patients with hypoxemia at baseline, whereas the remainder excluded only those with severe baseline hypoxemia (PaO2 to FiO2 ratio <100). Median follow-up duration was 3 months, with a range of 14 days to 12 months.

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