Influence of total body irradiation dose rate on idiopathic pneumonia syndrome in acute leukemia patients undergoing allogeneic hematopoietic cell transplantation

Idiopathic pneumonia syndrome (IPS) is a major cause of significant morbidity and mortality during allogeneic hematopoietic cell transplantation (HCT). Total body irradiation (TBI) dose rates have been implicated in the development of IPS, however there is no consensus regarding optimal dose rate. This single institution study includes 202 acute leukemia patients treated on a standard TBI-based myeloablative conditioning regimen for allogeneic HCT. Dose rates of >15 cGy/min were strongly associated with IPS.

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