Single-Cell RNA Sequencing Analysis Reveals Sequential Cell Fate Transition during Human Spermatogenesis

Single-cell RNA sequencing of 2,854 testicular cells reveals critical biological features of the sequential and stepwise development of spermatogonia, spermatocytes, and spermatids during human spermatogenesis. Moreover, altered transcriptional patterns were identified in a NOA patient, supporting the value of scRNA-seq for diagnosis and dissecting the underlying mechanisms of male infertility.

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