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Δευτέρα 16 Ιουλίου 2018

The clinical significance of PINX1 expression in papillary thyroid carcinoma

PIN2/TERF1 interacting telomerase inhibitor 1 (PINX1) is a telomerase inhibitor located on human chromosome 8p23, and also act as a tumor suppressor in several types of cancers, including breast, gastric, ovarian and bladder cancer; However, the role of PINX1 expression in papillary thyroid carcinoma (PTC) has not been defined. Therefore, we investigated the role of PINX1 expression in PTC by analyzing the correlation between PINX1 expression and various clinicopathological factors. Immunohistochemistry for PINX1 was performed using a tissue microarray of samples taken from the 160 patients with PTC.

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