Non-measurable speckled contrast-enhancing lesions appearing during course of disease are associated with IDH mutation in high-grade astrocytoma patients

Clinically asymptomatic, speckled contrast-enhancing lesions (≤ 0.5 cm) (SCEs) appeared frequently during course of disease in patients with gliomas and challenge the definition of progression and clinical management. Appearance of SCEs was significantly associated with IDH mutation in astrocytoma WHO °III and glioblastoma and with a favorable prognosis in glioblastoma. Most SCEs remained stable or disappeared without treatment necessitating a careful definition of progression and its confirmation in follow-up MRIs prior to initiation of treatment.

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