Epstein-Barr Virus–Associated Genital Ulcers: One Cause of Lipschütz Ulcer

Acute Epstein-Barr virus (EBV) infection is most often associated with a clinical presentation of pharyngitis, fever, lymphadenopathy, and fatigue. There has been a recent recognition of the association of EBV with genital ulcers, predominately in females. Over 100 years ago, Lipschütz (Arch Dermatol Syph (Berlin). 1913;114:363–395) described a series of females with severe genital ulcers, which had 3 suspected causes: herpes simplex virus infection, Behçet syndrome, and what he termed ulcus vulvae acutum (UVA). I wish to present the case of a young female who presented with UVA in the context of an acute EBV infection. The possible pathogenic role of EBV in UVA will be reviewed. Correspondence to: Joe Dylewski, MD, Division of Microbiology and Infectious Diseases, St Mary's Hospital, 3830 Lacombe, Montreal, Quebec, Canada H3T 1M5. E-mail: joe.dylewski@ssss.gouv.qc.ca. The author has no funding or conflict of interest to disclose. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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