Are Patients Receiving the Combination of Vancomycin and Piperacillin-Tazobactam at Higher Risk for Acute Renal Injury?

Authors included 15 published studies and 17 abstracts (24,799 patients total). Of these, 6 studies compared vancomycin and piperacillin-tazobactam with vancomycin monotherapy, 8 studies compared vancomycin and piperacillin-tazobactam with vancomycin plus another β-lactam, 4 studies compared vancomycin and piperacillin-tazobactam with piperacillin-tazobactam monotherapy, and 3 made multiple comparisons. Mean patient age varied between 48 and 74 years. Antibiotic administration (continuous or extended), comorbidities, infection type, and concomitant infections were not uniform across included studies.

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