The Expansion of Myeloid-Derived Suppressor Cells Is Associated with Joint Inflammation in Rheumatic Patients with Arthritis

Introduction. We investigated the proportion of myeloid-derived suppressor cells (MDSCs) and their subsets in patients with rheumatic diseases and clarified the association between these cells and the patient clinical data. Methods. Patients with rheumatic diseases and healthy controls were recruited. The clinical characteristics were obtained. The MDSCs and their subsets were marked with fluorescently labelled antibodies and were then analyzed with flow cytometry. Results. The patients included 31 with RA, 21 with AS, 14 with OA, 11 with SLE with arthritis, 13 with SLE without arthritis, 9 with Gout, 10 with HUA, and 25 healthy controls. The proportions of MDSCs, M-MDSCs, and G-MDSCs were higher in patients with RA than in healthy controls (6.56±6.77% versus 1.46±0.96%, 2.52±3.81% versus 0.35±0.35%, and 1.13±1.64% versus 0.18±0.14%; p

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