Optimizing the Role of Surgery and Radiotherapy in Urethral Cancer Based on Histology and Disease Extent

Optimal management of urethral carcinoma is unknown. A national hospital-based registry was used to evaluate the association of varying local therapies (surgery, radiotherapy, or surgery and radiotherapy) with survival. Overall, surgery and radiotherapy was associated with improved outcomes in locally advanced patients, but subset by histology revealed that adenocarcinoma and transitional cell carcinoma patients experienced improved survival in association with radiotherapy (either definitively or in addition to surgery), while squamous cell carcinoma patients experienced similar survival with surgery and/or radiotherapy.

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