Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production

Iron accumulation is observed in the brain of patients with neuroinflammatory diseases, yet its functional significance is poorly understood. Wang et al. demonstrate that iron promotes T cell pathogenicity by protecting RNA-binding protein PCBP1 from proteolysis, thereby promoting PCBP1-mediated stabilization of GM-CSF mRNA. These findings indicate that iron homeostasis can be targeted to suppress pathogenic T cells for treatment of neuroinflammatory diseases.

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