A database of predicted binding sites for cholesterol on membrane proteins, deep in the membrane

The outer membranes of animal cells contain high concentrations of cholesterol of which a small proportion is located deep within the hydrophobic core of the membrane. An automated docking procedure is described that allows the characterization of binding sites for these deep cholesterol molecules on the membrane-spanning surfaces of membrane proteins and in protein cavities or pores, driven by hydrogen bond formation. A database of this class of predicted binding site is described, covering 397 high resolution structures.

https://ift.tt/2yL83v8