Sleep and Circadian Rhythms in Severely Brain-Injured Patients – A Comment

Lately, several publications have focused on circadian rhythms and sleep in patients with disorders of consciousness (DOC), namely patients who, following severe brain injury, are in an unresponsive wakefulness syndrome/a vegetative state (UWS/VS) or in a minimally conscious state (MCS) (Cologan et al., 2013; de Biase et al., 2014; Forgacs et al., 2014; Landsness et al., 2011; Pavlov et al., 2017; Rossi Sebastiano et al., 2018). Circadian rhythms, i.e., variations in biological processes with a period length of about 24 hours, have been discovered in virtually all biological organisms.

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