Sepsis-3 and simple rules

Sepsis is a complex syndrome, where complexity is defined as having multiple interdependent parts. It has been a challenge to define it, and, as our understanding has evolved, so its definition has changed from the first iteration in 1991,1 to the second in 20012 and now a third in 2016.3

At its most basic sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.3 Singer et al have suggested that this organ dysfunction can be identified using an acute change in the Sequential Organ Failure Assessment (SOFA) score ≥2 points as a result of the infection.3

The problem with the SOFA score is that it does rely on some laboratory data, which makes it difficult to use outside hospital or at the 'front door'. Singer et al then developed what they described as a 'parsimonious...

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