Cancers, Vol. 10, Pages 148: p53-Autophagy-Metastasis Link

Cancers, Vol. 10, Pages 148: p53-Autophagy-Metastasis Link

Cancers doi: 10.3390/cancers10050148

Authors: Tatiana V. Denisenko Anastasia D. Pivnyuk Boris Zhivotovsky

The tumor suppressor p53 as the "guardian of the genome" plays an essential role in numerous signaling pathways that control the cell cycle, cell death and in maintaining the integrity of the human genome. p53, depending on the intracellular localization, contributes to the regulation of various cell death pathways, including apoptosis, autophagy and necroptosis. Accumulated evidence suggests that this function of p53 is closely involved in the process of cancer development. Here, present knowledge concerning a p53-autophagy-metastasis link, as well as therapeutic approaches that influence this link, are discussed.

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