Evaluation of Glioblastoma (GBM) Response to Therapy with Chemical Exchange Saturation Transfer (CEST)

Early determination of Glioblastoma (GBM) response to standard 6-week chemo-radiation may allow for adjusting subsequent therapy in non-responders. Chemical exchange saturation transfer (CEST) probes cellular and metabolic characteristics of the tumor which are more sensitive to treatment-induced changes (compared to tumor size change). CEST was able to identify those tumors that would progress early after treatment completion based on the imaging acquired as early as two weeks into the treatment course. Moreover, certain CEST metrics were able to characterize GBM aggressiveness even before treatment.

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