Different biochemical patterns in Type II and Type III mixed cryoglobulinemia in HCV positive patients

Reversible cryoprecipitability of proteins is observed as a concomitant feature of immune complex formation. Mixed cryoglobulinemia (MC) is systemic vasculitis, associated with mixed IgM and IgG cryoglobulins (CGs) showing rheumatoid factor (RF) activity. It is frequently associated with hepatitis C virus (HCV). This study investigates the presence of IgG RF and anti-nuclear antibodies (ANA) in cryoprecipitates of patients with Type III and Type II MC, to understand the biochemical patterns associated with different types of MC to a greater degree.

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