Decorin modified umbilical cord mesenchymal stem cells (MSCs) attenuate radiation induced lung injuries via regulating inflammation, fibrotic factors and immune responses

Effective strategies are still lack for treating RILI. In experimental RILI model, we found MSCs.DCNcould home to injured lung tissues and produced decorin protein. Then, MSCs secreted cytokines to attenuate inflammation, regulated apoptosis and proliferation to promote tissue repair, and modulated pro-fibrotic factors to inhibit fibrosis. Secreted decorin protein inhibited pro-inflammatory and pro-fibrotic factors to enhance functions of MSCs. Therefore, MSCs.DCN might be a potential strategy for treating RILI.

https://ift.tt/2IZl44A