Antimicrobial Activity of Murepavadin Tested against Clinical Isolates of Pseudomonas aeruginosa from the United States, Europe, and China [PublishAheadOfPrint]

Murepavadin (formerly POL7080), a 14-amino-acid cyclic peptide, and comparators were tested by broth microdilution method against 1,219 isolates from 112 medical centers. Murepavadin (MIC_50/90, 0.12/0.12 mg/L) was 4- to 8-fold more active than colistin (MIC_50/90, 1/1 mg/L) and polymyxin B (MIC_50/90, 0.5/1 mg/L) and inhibited 99.1% of isolates at ≤0.5 mg/L. Only 4 isolates (0.3%) exhibited murepavadin MIC >2 mg/L. Murepavadin was equally active against isolates from Europe, the United States, and China.

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