Achieving Stability in Oxygenation: Servo-Controlled Oxygen Environment as a First Step to Fully Automated Oxygen Control?

Oxygen is one of the drugs most frequently administered to neonates, yet the way it is dosed has not changed much over the years: It largely depends on the tightness of the alarm levels chosen on the bedside monitor and the alertness of the bedside staff how closely oxygen levels are controlled.1 This seems odd given the data from the various oxygen trials performed in the last 10-15 years comparing a higher with a lower pulse oximeter saturation (oxygen saturation [SpO2])-target range.2-4 A small (3%) difference in mean SpO2 between the high and low SpO2-target group in these trials affected the rate of important outcomes such as mortality or necrotizing enterocolitis.

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