Prediction of secondary generalization from a focal onset seizure in intracerebral EEG

Approximately 30% of patients with focal epilepsy are unresponsive to antiepileptic medications and many are considered surgical candidates (Johnson and Krauss, 2016). These patients continue to experience several physical and physiological complications and the conditions become worse when their uncontrolled seizures evolve from focal to bilateral tonic-clonic seizure (van Mierlo et al., 2014). Such seizures severely affect the patient's safety and quality of life (Yang et al., 2017; Yoo et al., 2014).

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