Front cover story: Eur. J. Immunol. 3'18

Our front cover features pseudocolored serial confocal z-stack images of B cells expressing one of two different isoforms of human membrane-bound IgE (mIgE), which were visualized by staining with fluorophore-labeled anti-IgE antibodies after fixation and permeabilization of the cells. The images are taken from Vanshylla et al. (pp. 441–453), who show that the short isoform of human mIgE is readily expressed on the B cell surface as part of the B cell antigen receptor, whereas the long isoform of human and primate mIgE is efficiently retained in the endoplasmic reticulum and as a consequence has limited potential to signal activation of IgE-switched B cells.

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