Betweenness Centrality of Intracranial Electroencephalography Networks and Surgical Epilepsy Outcome

Epilepsy is a neurological disorder in which patients suffer from recurrent seizures. Pharmacologically resistant epilepsy patients have been increasingly referred for surgical options, but despite many advances in non-invasive pre-operative localization modalities, the rate of seizure freedom after epilepsy surgery has been relatively stagnant at 60-70% after the first year, and decreasing with post-operative follow-up.(Spencer et al., 2008, Bulacio et al., 2012) The goal of surgery is to identify discrete parts of the brain that give rise to seizures (frequently with intracranial EEG - iEEG) and resect them.(Luders et al., 2001) Surgical failures are most frequently attributed to either incomplete resection of a seizure focus or missed identification of additional foci.(Englot et al., 2014a; Englot et al., 2014b)

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