Overexpression of IL-35 in intrahepatic cholangiocarcinoma isa prognostic indicator after curative resection

Summary

Interleukin-35 (IL-35) is implicated in tumorigenesis, but the exact impact on intrahepatic cholangiocarcinoma (ICC) is not clearly. The aim of present study was to explore the specific effect of IL-35 on patient prognosis. Additionally, we formulated an effective prognostic nomogram for ICC patients after curative resection. Immunohistochemistry (IHC) was applied to explore IL-35 expression as well as IL-35R in 102 ICC patients. The results showed IL-35 was highly expressed in ICC tumor tissues and was positively associated with lymph node metastasis, TNM stage and vascular invasion and was independent prognostic factor for patients' OS and RFS. High expression of IL-35R (gp130 and IL-12Rβ2) were also observed in ICC cancer tissues, but only gp130 was independent prognostic factor for OS and RFS and indispensable in IL-35-mediated ICC clinical prognosis. The nomogram comprising CEA, lymph node metastasis, IL-35 and gp130 expression achieved better predictive accuracy compared with TNM stage for OS. Our data support that high IL-35 expression correlates with ICC aggressiveness and emerges as a valuable biomarker for evaluating ICC progression and prognosis in clinical work.

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