Dose Sculpting Intensity Modulated Radiation Therapy for Vertebral Body Sparing in Children with Neuroblastoma

Long-term survivors of high-risk neuroblastoma have an increased incidence of musculoskeletal anomalies. Historically, the radiation field to the primary site was designed to cover adjacent vertebral bodies to minimize growth deformities. With intensity modulated radiotherapy (IMRT), one can shape dose distributions to spare vertebral bodies without sacrificing tumor coverage. We reviewed our institution's experience with dose sculpting IMRT to assess its effect on vertebral body growth.

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