Initial Clinical Investigation of [18F]Tetrafluoroborate PET/CT in Comparison to [124I]Iodine PET/CT for Imaging Thyroid Cancer

Aim Recently, [18F]tetrafluoroborate ([18F]TFB) has been introduced as a versatile PET probe for imaging the human sodium/iodide symporter activity. This pilot study aimed to compare [18F]TFB-PET/CT with [124I]NaI-PET/CT imaging in thyroid cancer patients. Methods Nine patients with newly diagnosed differentiated thyroid cancer underwent both [18F]TFB- and [124I]NaI-PET/CT after total thyroidectomy. PET/CT scans were visually analyzed for the presence of remnant thyroid tissue and for metastatic lesions on a patient and lesion basis. For semiquantitative analysis, thyroid remnant/tumor to blood pool ratios were calculated. Results All patients presented with positive [18F]TFB and [124I]NaI-PET/CT scans. Retention of 124I in remnant thyroid tissue was significantly higher as compared with [18F]TFB (P

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