Temporal Layering of Signaling Effectors Drives Chromatin Remodeling during Hair Follicle Stem Cell Lineage Progression

How external signals interface with chromatin to coax stem cells along distinct tissue lineage programs remains a mystery. Here, Adam et al. combine epigenomic, genetic, single-cell transcriptome, and chromatin sensor data to show how new fates are acquired through temporal layering of signaling effectors atop established chromatin platforms.

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