An Ounce of Prevention May Be Worth Many Pounds of Cure

Studies in animals and humans have shown that transient inflammation (infectious and noninfectious) predisposes children to developing long-term functional gastrointestinal disorders (FGIDs).1-4 Acute gastroenteritis of bacterial,1,2 viral,2 and parasitic5 origin is a known risk factor for irritable bowel syndrome and functional dyspepsia. Henoch–Schönlein purpura3 and cow's milk protein allergy4,6 (CMA) also are associated with an increased risk of FGIDs in children. In 2011, Saps et al compared a cohort of 52 school-age children diagnosed with CMA as infants with their healthy siblings and used age-appropriate validated questionnaires (Questionnaire of Pediatric Gastrointestinal Symptoms) to diagnose FGIDs per the Rome III criteria.

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