Reply to Gupta-Wright et al

We thank Gupta-Wright et al for their insightful comments on our article and enthusiastically echo many of their points [1, 2]. Indeed, we share their concern regarding the difficulty of ruling out tuberculosis coinfection among patients with confirmed disseminated nontuberculous mycobacterial (NTM) infection who have a positive Determine TB-LAM lateral flow assay (LF-LAM) result. For that reason, in our high-burden tuberculosis setting, it is our policy to always err on the side of initially treating such patients for both infections while continuing to search for definitive evidence of tuberculosis coinfection.

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