Possible redundant data in the network meta-analysis of pharmacological therapies for opioid-induced constipation

We read with great interest the recent systematic review and network meta-analysis by Sridharan and Sivaramakrishnan, (1) which synthesised data from 23 separate articles reporting randomised controlled trials (RCTs) of pharmacological therapies for opioid-induced constipation (OIC). After pooling and analysing the results from these articles, the authors concluded that subcutaneous methylnaltrexone performed better than other medications for OIC.

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